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Earlier GLP-1R agonists could cross into the brain and do have effects on the mouse model of Alzheimers disease, but the newer drugs have been designed to stay in the blood for a very long time and do not really cross into the brain, said Hlscher

Mechanistic Novelty Dihexa and Cerebrolysin are not direct competitors they occupy entirely different tiers of the evidence hierarchy, and comparing them reveals more about the drug development process than about relative efficacy

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