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It can be taken orally or by injection and there has been no upper limit of toxicity established, making vitamin B12 a safe vitamin to supplement

"While we acknowledge your response that an abrupt shortening of the enrollment period led to challenges and mistakes, your response is inadequate because, regardless of the length of the enrollment period, you are still responsible for ensuring that subjects meet protocol-specified eligibility criteria before you enroll them into the study," said FDA

Other studies have also suggested a limited effect of PRP in treating patellar tendinopathy [14, 25]