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Tesamorelin (Egrifta, and the later reformulations Egrifta SV and Egrifta WR) is indicated to reduce excess visceral (abdominal) adipose tissue in patients with HIV-associated lipodystrophy a condition in which antiretroviral therapy and HIV itself drive an abnormal accumulation of deep abdominal fat

Long-term safety data in extended rodent studies (90+ days) would be essential before translating this to human protocols

Its very origin story is rooted in one of the most hostile environments in the bodythe stomach

However, the metabolic activation and protein adduct formation, also in mitochondria, are only marginally lower in rats compared to mice but there was no relevant mitochondrial dysfunction and oxidant stress in rats [124]