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This imbalance causes fat cells to enlarge abnormally, disrupting the nutrient signaling pathways that contribute to obesity [7]

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Real World Impact: Current Use and Outcomes These medications are no longer niche, they're influencing population level trends: Rapid Growth in Use In the U.S., reported use of GLP-1 weight loss drugs has more than doubled in the past year, from about 5.8% of adults in early 2024 to over 12% in 2025 Women tend to use these medications at higher rates than men, with 15.2% vs

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