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Studies have demonstrated that the lifespan of mice with OC is considerably reduced owing to the continuous activity of N1ICD, which leads to the aging of endothelial cells, increased expression of chemokines and the adhesion molecule VCAM1, and facilitates recruitment of neutrophils and invasion of tumors (70,74)

Figure 5 Deferoxamine chelates iron and inhibits ACSL4, while rosmarinic acid activates Nrf2 by disrupting its Keap1 interaction

Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death