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Many people experience side effects like nausea, constipation, or fatigue early on, though these often ease as the body adjusts to the medication

Hepcidin (HEPC), which comes from the liver, can sense how much iron is in the body, stop intestinal absorption of iron and prevent iron release

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17 In addition to these findings, the SUSTAIN-6 trial also showed that semaglutide can offer a significant reduction in the risk of new or worsening nephropathy including persistent macroalbuminuria, increase in serum creatinine or the need of renal replacement therapy