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McGraw-Hill / Lange Rivera FB et al (2024): Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials
It is not known whether this risk applies to humans, but Saxenda is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Plemel et al., 2011)
The rationale follows directly from the selectivity profile: aged animal models have elevated baseline HPA reactivity, and running GHRP-2s cortisol co-activation on top of that creates an impossible interpretation problem
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