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The following table summarizes the incidence rates of adverse events reported by at least 1% of patients who received dihydroergotamine mesylate nasal spray for the treatment of migraine headaches during placebo-controlled, double-blind clinical studies and were more frequent than in those patients receiving placebo

Cleavage of the disulfide bonds Due to the high reactivity of -SH group, thiols present in plasma occur mainly in forms of symmetrical and mixed disulfides

thus, the phenotype is manifest fully in males whereas female heterozygotes display varying degrees of G6PD deficiency, due to alternate X-chromosome inactivation 3,4

Some research suggests the drug also may have a direct effect on your sense of taste