amgen glp-1 Will 2 incretin drugs be better than 1 to for weight loss & to prevent weight regain? @Amgen thinks so, releases @Nature phase 1 study of AMG 133 (maridebart cafraglutide) a combination ADA: Amgen talks Repatha, GLP-1

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Peptides may help improve: Insulin sensitivity Fat metabolism Mitochondrial efficiency Glucose regulation Examples: Potential benefits: Reduced visceral fat Better blood sugar control Lower inflammatory burden 5

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The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation