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Patients should understand that individual responses may vary and that lack of response should prompt reassessment of the treatment approach rather than unlimited dose escalation

Quick Takeaways GHK-Cu is a naturally occurring copper-binding peptide that powerfully upregulates collagen synthesis and skin remodeling Most topical collagen products cannot penetrate your system dermally (through the skin), and do almost nothing at the tissue level The best results for loose skin come from the combination of systemic peptides and topical application strategies Peptides for loose skin work through receptor-mediated signaling and gene expression, rather than surface-level hydration Why Loose Skin Is a Biology Problem, Not a Cosmetic One The fitness and wellness industry has conditioned people to think loose skin is just a cosmetic inconvenience or an after-effect of massive weight loss

Thus, although oral L-carnitine may offer potential benefits in the prevention of cellulite adipose, its efficacy remains to be demonstrated in clinical studies

Mar Drugs 17:628