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It doesn't mean the active ingredient itself is unresearched - semaglutide and tirzepatide as active pharmaceutical ingredients have extensive clinical evidence bases

But it is not for children or pregnant women without doctor advice

Berberine is not recommended during pregnancy due to potential risks to the fetus and concerns about neonatal jaundice from displacement of bilirubin, which could lead to kernicterus

When compared to other strategies, GLP-1R agonists occupy an intermediate position, more effective than lifestyle or other pharmacological interventions, but less invasive than bariatric surgery, underscoring their unique therapeutic niche