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48%), both groups are susceptible to liver failure and generate referrals for liver transplantation.2,6 Although the majority of patients experience mild adverse reactions, such as hepatitis, cholestasis or asymptomatic liver enzyme elevation, APAP hepatotoxicity is generally estimated to account for approximately 48% of acute liver failure diagnoses.13 Moreover, studies have shown that 29% of patients with acute liver failure secondary to APAP toxicity undergo liver transplant, and that these cases have a 28% mortality rate.1 With the advent of APAP/opioid combination analgesics and the ever-growing number of prescription narcotics being prescribed by medical practitioners, a larger number of patients have been placed in harms way as they are at significant risk of APAP hepatotoxicity

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