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This combination can accelerate fat loss for some patients, particularly those whose GLP1R and GIPR genetic variants (measured by PlexusDx's Precision Peptide Genetic Test) show high receptor sensitivity

These therapeutic effects appear to be mediated through curcumins modulation of key neuromodulators, with particularly noteworthy differential regulation observed between brain and gut tissues: while BDNF and phosphorylated CREB (p-CREB) levels increased in hippocampal tissue, their expression decreased in colonic tissues (Yu et al., 2015)