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10.1016/j.biopsych.2018.12.020 128

Advanced characterization approaches may also integrate: glycosylation analysis of biosimilars disulfide bond mapping in biosimilars Multi-attribute monitoring (MAM) Ultra-high-resolution MS platforms Emerging trends include: AI-assisted spectral interpretation Ultra-high-resolution MS platforms Automated impurity identification Multi-attribute monitoring (MAM) Native MS for higher-order structure analysis Advanced bioinformatics integration These innovations are expected to improve analytical throughput, sensitivity, and regulatory confidence

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