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Biopeptides derived from medicinal plants have been shown to activate specific signalling pathways, in particular the AMPK pathway, a serine/threonine kinase that is activated when cellular energy levels are low, and which signals to stimulate glucose uptake, fatty acid oxidation in adipose (and other) tissues (90), glucose transporter protein (GLUT)4 translocation and mitochondrial biosynthesis, while inhibiting protein and glycogen synthesis and improving insulin sensitivity and glucose homeostasis

10.1056/NEJMoa0708857 N