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Modulation of GLP-1-Mediated [Ca 2+ ] i by Metformin MIN6 cells were stimulated with 10 nM GLP-1 or GIP in the presence of 5.5 or 16.7 mM glucose

As an important regulator in cancer metabolism, dysregulated GGCT expression has been confirmed to be closely associated with the progression of multiple malignancies [3,4,5,6,7,8,9,10]

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Specifically, the pcDNA3.1-GST DAF -ATP6AP1L transfection resulted in an ATP6AP1L gene expression level of 47 times that of the control, and the affinity cell sorting procedure significantly elevated the apparent expression level in the enriched cells by 253 times that of the control