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Other large clinical trials have found the drugs reduce the risk of chronic kidney disease progression and improve outcomes in several other age-related conditions, suggesting their benefits extend well beyond diabetes and weight loss

The role of 5-HT in upper gastrointestinal physiology remains unclear, due to a lack of suitable agonists and antagonists for human application (110)

These factors help a clinician understand medical need, risk level, and likely benefit

Difficult timing: John explains that oral semaglutide must be taken on an empty stomach and requires a 30-minute wait before eating, which can be hard to maintain long-term