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The PA process is in many cases muddled by a mix of factors, including: Varying interests, workflows, and motivations of PBMs, patients and prescribers Loads of clinical protocols, each presenting the potential for delays and mistakes Manual reviews of prior authorization requests and medical charts by clinicians Lack of standardization among plan administrators and PBMs Hundreds of health plans and third-party payers Not All Prior Authorization Requests Are Reviewed by a Clinician on the PBM Side

Yet, its numerous signaling targets involving the human ovary will need to inform future study, and off-label use of SG should be discouraged in the meantime

Most claims supporting the practice are anecdotal

In rats, Zepbound causes thyroid C-cell tumors