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NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia

Our MitoTracker Green assay (MT Green) revealed that following treatment with melatonin, ILC2 mitochondria increased in size ( Figure 5L ) whilst MitoTracker Red (MT Red) and TMRM assays suggested that mitochondrial membranes were significantly depolarized following melatonin treatment ( Figures 5M, N )