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The catalytic site of the mitochondrial glycerol phosphate dehydrogenase is on the outer surface of the inner membrane, allowing ready access to the product of the second, or cytosolic, glycerol-3-phosphate dehydrogenase

This allows it to maintain the usual efficacy of glucocorticoid regimens while also achieving a better-tolerated side effect profile, according to Catalyst Pharmaceuticals, which will commercialize the drug in North America

The compact and symmetric structure of rosmarinic acid (Table 1) binds specifically to A, inhibits polymerization into the fibrillar form, and inhibits tau aggregation [170,173], imparting protection in AD and other neurogenerative conditions