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This mechanism has been associated with NSAID-related gastrointestinal (Watanabe 2011) and liver toxicity (Doi 2010

These NPs had an average particle size of 136.54.4 nm, which is suitable for BBB permeation, and demonstrated sustained drug release for up to 144 hours with no initial burst release

Elevated cAMP activates protein kinase A (PKA), which phosphorylates multiple targets including ion channels, transcription factors (notably CREB), and components of the insulin secretory machinery