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Study Design Highlights Models: Caco-2 intestinal cell model, animal intestinal function model, human crossover RCT Human dose: 50 mg APS with L-arginine (single dose crossover) Outcomes: L-arginine absorption and bioavailability, amino acid transport pathway activity, intestinal structure and function markers Key Findings (What the Study Showed) Caco-2 model: Dose-dependent increases in L-arginine movement across the intestinal lining, associated with increased activity of amino acid transport pathways Animal models: Improvements in markers related to intestinal condition and physiological resilience during periods of stress

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Biochem Biophys Res Commun 405 , 173179, doi: 10.1016/j.bbrc.2011.01.002 (2011)