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12 In pancreatic -cells, signaling mediated by -arrestin 2 activates the MAPK/ERK pathway and CREB at pharmacological levels, influencing insulin secretion and metabolic adaptation (Figure 1, right)

Low levels of GSH have been reported in cardiovascular disease, cancer, AIDS, autism, alcoholism, and debilitating neurodegenerative diseases such as Alzheimer's and Parkinson's