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Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]

Specifically, teplizumab is an anti-CD3 antibody that interferes in the autoimmune destruction of pancreatic beta cells to help delay type 1 diabetes

10.1161/01.res.61.5.735 Circ

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