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In a rigorous review of 19 randomized controlled trials that enrolled type 2 diabetics, acarbose was found to significantly reduce HbA1C levels when given alone or as add-on treatment with other antidiabetic drugs (Derosa 2012)

VRK2 protects PC cells from ferroptosis by facilitating SLC7A11 trafficking Since SLC7A11-mediated cystine uptake and subsequent biosynthesis of GSH detoxifies phospholipid peroxidation and protects cells from ferroptosis [26], we speculated that VRK2-deficient PC cells, vulnerable to GSH inhibition is associated with ferroptosis