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The most common side effects are mild and transient, including temporary bloating, gas, or changes in bowel habits during the first few days of supplementation

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Using Tuttle et al estimates [6] (which agree well with our current estimates) combined with the estimated loss of sulfate due to acetaminophen conjugation, a large segment of the population, which include those most vulnerable to OA, would appear to be sulfur deficient or receiving marginal intakes