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For instance, administering IGF-1R mAbs in cancer trials was reported to result in increased adverse events in younger populations 34 , including insulin resistance, possibly due in part to disruption of the somatotropic axis and associated deleterious effects of excess GH 41,42

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Clinicians should adopt a balanced perspective , recognising that the overall health benefits of appropriate weight loss in type 2 diabetes typically outweigh theoretical concerns about bone density, whilst remaining vigilant about bone health in higher-risk individuals

Pancreatitis: Some individuals may experience pancreatitis, which is inflammation of the pancreas