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In vitro mechanistic studies revealed that complement proteins C3a and C5a increased the expression of profibrotic ECM proteins in macrophages and proximal tubule epithelial cells

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What they did: They took 80 rats (Wistar strain), completely transected their Achilles tendon (the strongest tendon in the body) and divided them into 3 groups: Control , saline BPC-157 by injection , 10 g/kg into the abdominal cavity BPC-157 in drinking water , 10 g/kg orally After 14 days they tested the tensile strength of the healed tendon and performed histology (microscopic examination of the tissue)