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Why Its Devastating: May be permanent even after stopping the drug Currently no cure, only symptom management Severely impacts quality of life May require years of treatment or permanent dietary changes Some patients need feeding tubes for life Legal Significance: This is the primary injury in most GLP-1 lawsuits

Side effects typically begin to improve during the same period as medication levels decrease

EZH2, the H3K27 methyltransferase responsible for gene silencing, shows 2.4-fold increased activity, reinforcing repressive chromatin states in spermatogonial cells (94)

The lump is non-infected lipotropic depot