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After supply disruptions for semaglutide and tirzepatide ended, facilities continued producing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) using compounded formulations that include added ingredients, according to a study published in JAMA Health Forum (doi:10.1001/jamahealthforum.2026.2207)

In the brain, GLP-1 activates appetite control centers, increasing satiety and reducing food intake, which lowers the amount of glucose entering the bloodstream

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Due to its necessity in myelin sheath maintenance, thiamine deficiency may also cause peripheral sensorimotor neuropathy [3]