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17,18 In a biological context, photosensitive folates circulate in the vascular system, along with a number of compounds including the flavins and porphyrins, which are natural photosensitizers

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Metabolic differences between C and C plants also modulate vulnerability: in C species, drought primarily affects photosynthesis through stomatal closure and reduced enzymatic activity, whereas in C species, heat intensifies photorespiration and destabilizes both energy distribution and Rubisco activity(Essemine, et al., 2020)

Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27