No serious dose-limiting toxicities or unexpected safety signals were identified in Phase 1 trials, supporting progression to Phase 2 development
doi: 10.3389/fcell.2021.646113 Received 25 December 2020 Accepted 09 June 2021 Published 07 July 2021 Volume 9 - 2021 Edited by Rossella Rota, Bambino Ges Childrens Hospital Scientific Institute for Research, Hospitalization and Healthcare, (IRCCS), Italy Reviewed by Jing Yang, University of South China, China
OCTN2 is localized on various cell membranes and can transport acetylcarnitine into cells as well as ensure acetylcarnitine uptake from the gut and across the bloodbrain barrier (BBB) [59]
Analysis for plasma ALT, AST, alkaline phosphatase, TG, cholesterol, LDL, and HDL was performed by the Pathology core at The Centre for Phenogenomics