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Carrying a high volume of inflammatory fat cells forces your heart to work significantly harder, impairing your microcirculation and increasing blood vessel resistance

J Biol Chem (2013) 288(35):2508897.10.1074/jbc.M113.452516 194 EverardALazarevicVDerrienMGirardMMuccioliGGNeyrinckAMet alResponses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice