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Screening for hypothyroidism in newborns with PWS often produces negative results, as their levels of TSH and total T4 are typically within the normal range and comparable to those of healthy individuals ( Congenital hypothyroidism appears to be more common in infants and toddlers with PWS, with the highest incidence in the 1 to 3-year-old group, gradually decreasing over time ( The influence of sex on thyroid status and whether genotype could be associated with a different pattern of thyroid function still remains unclear

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N-acetyl cysteine (NAC) is a stable form of the non-essential amino acid cysteine