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As an embodiment of the invention, R in the compound 1 and the compound 4 is tert-butyl, and the specific synthetic route I' is as follows: wherein, the substituent R in the compound 1, the compound 2 and the compound 4 is tert-butyl

But targeting GLP-1 receptors in the brain will likely need a small molecule drug

There were no new safety concerns found in the study, which researchers note is encouraging since the SELECT trial is the largest and longest (4.5 years) trial of semaglutide in adults without Type 1 or Type 2 diabetes

expression can be carried out at a pH of about 5.0 to about 7.5 and/or at a temperature of about 18C to about 42C