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Clinical data showed that participants who skipped titration steps or escalated too quickly experienced nearly double the rate of gastrointestinal adverse events

Moreover, SS-31 protected the endothelial function of renal arteries because the vasodilatory response to acetylcholine in resected renal arterial rings was impaired in MetS but normal in MetS/SS-31

For DSIP specifically, the substitution is far more consequential, and the reason follows directly from the half-life: Subcutaneous absorption competes with a 24 minute clearance

11 This guideline was based on Medline, PubMed, and consensus conference proceedings and categorizes what is mandatory, as well as recommended, for an IC diagnosis