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Lifestyle Modifications To minimize side effects and help with your treatments effectiveness: Maintain a healthy diet: Focus on calcium-rich foods and limit sodium to help prevent bone loss and control blood pressure Exercise regularly: Weight-bearing exercise can help maintain bone density and muscle mass Avoid alcohol: Alcohol can increase the risk of stomach ulcers and may interfere with the medications effects Practice good hygiene: Frequent handwashing and avoiding sick contacts can help prevent infections Take medications as prescribed: Never adjust your prednisone dose without talking to a healthcare professional Take Away Prednisones ability to reduce inflammation and regulate your immune system activity has made it effective for treating conditions ranging from severe allergic reactions to asthma, arthritis, inflammatory bowel disease and adrenal, blood or bone marrow conditions