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Accompanied by impaired BBB integrity, these peripheral immune factors gain access to the CNS, where they mediate neuroinflammatory responses, resulting in synaptic damage and neuronal dysfunction

Nonetheless, many uncertainties and challenges remain, particularly regarding specific ferroptosis pathways, immunometabolic regulation, and clinical translational applications

Endotoxin contamination Endotoxins are lipopolysaccharide fragments from the cell walls of gram-negative bacteria

Role of Tight Junctions in Crucial Physiological Processes The paracellular pathway includes several important aspects: (1) the ability of TJ to restrict paracellular diffusion processes, acting as a paracellular barrier