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Extracellular superoxide dismutase enhances recruitment of immature neutrophils to the liver

Results Establishment of CRC Drug-Tolerant Persister Cell Models While modeling the response to the chemotherapeutic drug 5-FU in the CRC cell line HCT116, which has exquisite sensitivity, we observed that the vast majority of the cells were killed within 9 days of exposure to the drug at a concentration 10-fold higher than the IC 50 value ( Figure 1A )

The benefit was not observed in all-cause death (HR 0.99, 95% CI 0.841.15), hospitalization for heart failure (HR 1.04, 95% CI 0.891.22), cardiovascular death (HR 0.95, 95% CI 0.791.16), myocardial infarction (HR 0.88, 95% CI 0.711.08), stroke (HR 1.03, 95% CI 0.751.43) and death or hospitalization for HF (HR 1.07, 95% CI 0.781.46)