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They require ongoing licensed physician supervision

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The post lists pre-existing medullary thyroid cancer, a personal or family history of multiple endocrine neoplasia type 2, uncontrolled type 1 diabetes, severe renal impairment with an eGFR under 30, and pregnancy or lactation

Legitimate access is limited to participation in authorised clinical trials or, if granted, MHRA early access mechanisms such as the Early Access to Medicines Scheme (EAMS) neither of which has been announced for retatrutide at this time