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However, these increases are far smaller than what prescription GLP-1 medications achieve through direct receptor activation

Cell transfection Transient transfections were performed using Lipofectamine and Plus Reagent (Thermo Fisher) using methodology described previously by our laboratory for HEK293 cells 68

February 3, 2024

This fundamental difference explains why GLP-1 drugs like semaglutide have emerged as powerful tools for weight management, while sitagliptin offers more modest metabolic effects