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Cyanocobalamin demonstrates superior stability in solution and during storage

Consistently, regardless of the initial positions of palmitate either located in the membrane as seen in the cryo-EM structure or placed outside of the membrane, our MD simulations found that the -carboxylate spacer stably inserted into the TM1-TM2 cleft and the 16-carbon palmitic chain is deeply buried in the receptor-lipid interface, contributing multiple strong contacts to stabilize the complexes (Supplementary Fig

On the reproductive axis, recent meta-analyses and RCTs suggest modest improvements in ovulation-induction pregnancy rates and androgen milieu, with reductions in LH and total testosterone in some studies (123)

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