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Paiva I, Seguin J, Grgurina I, Singh AK, Cosquer B, Plassard D, Tzeplaeff L, Le Gras S, Cotellessa L, Decraene C, Gambi J, Alcala-Vida R, Eswaramoorthy M, Bue L, Cassel J-C, Giacobini P, Blum D, Merienne K, Kundu TK, Boutillier A-L (2024) Dysregulated expression of cholesterol biosynthetic genes in Alzheimers disease alters epigenomic signatures of hippocampal neurons

These observations raise the possibility the ligand GLP-1(736) itself, by increasing intracellular cAMP, exerts a stimulatory rather than an inhibitory effect on glucagon secretion [57]

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The company itself acknowledges this limitation in its published disclosure language