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Diabetes Care 45:22712281 Krogvold L, Edwin B, Buanes T, Ludvigsson J, Korsgren O, Hyty H, Frisk G, Hanssen KF, Dahl-Jrgensen K (2014) Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

The exact reasons for this are still being investigated, but it is believed to occur through multiple mechanisms

The agency specifically noted that some patients were told by prescribers or telehealth platforms that topical application carried no risk of systemic side effects

In Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline 592 (National Academies Press, 1998)