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Schwiete Foundation and the Center for Multiscale Modelling in Life Sciences (CMMS) sponsored by the Hessian Ministry of Science and Art for funding and the Center for Scientific Computing at Goethe University Frankfurt for access to Goethe-HLR

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Lipoic acid contains two thiol (sulfur) groups, which may be oxidized or reduced

Hence, the significant decrease in the rate of ALA synthesis in ntrc and ntrc/trxf1 mutants can be explained by decreased amounts of GluTR and GSAAT as the result of a relative lack of reductants