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Results Evidence suggests that GLP-1RAs mitigate psoriasis severity through systemic effects, including weight loss and improved glycemic control, and local immunomodulation, such as the regulation of invariant natural killer T (iNKT) cells and AMPK activation in psoriatic plaques

The glucagon receptor raises theoretical concerns about heart rate increases (glucagon is known to increase heart rate), but clinical trial data has not shown significant safety issues in this regard so far

Regular soda's high sugar content can undermine blood glucose control, while carbonation may worsen common gastrointestinal side effects like nausea and bloating

Rybelsus also had low rates of hypoglycemia in patients with type 2 diabetes mellitus