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Mast cells, which are abundant in the developing brain and highly responsive to bacterial antigens, likely contribute to the abrupt neuroimmune activation in these children

Inflammatory microglia have several deleterious effects, including shifting astrocytes from a protective to an inflammatory phenotype via the secretion of extracellular vesicles and cytokines, such as IL1a, TNF, and C1q

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Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1