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Gene and protein delivery platforms Nanocarrier-enabled delivery of macromolecules, including genes, small interfering RNAs (siRNAs), and proteins, represents a paradigm shift in GLP-1R-targeted therapy, providing prolonged or programmable effects that outperform conventional small-molecule approaches in duration, precision, and disease specificity [213, 425, 426]

These changes alter liver metabolism, increase the risk of hepatic cirrhosis, and weaken liver function [32, 33]