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Recent studies have shown that glutamine deprivation can inhibit cholesterol synthesis in hepatocellular carcinoma (HCC) by inducing lipid autophagy, thereby reducing NADPH consumption during cholesterol synthesis and maintaining redox balance

Glutathione helps with the production of chemicals and proteins required by the body, as well as immune system activity

This review uniquely integrates the gastrointestinal and tumor microenvironment barriers encountered in oral chemotherapy for CRC and establishes the rationale for using nanoparticle-based drug delivery and for developing suitable nanoformulations to overcome these barriers and impart therapeutic effects