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Based on preclinical literature reviews, Pickart and colleagues proposed broader genomic effects, suggesting that, in sequencing models, GHK-Cu may influence approximately 31% of genes altered during skin aging, shifting expression patterns toward a younger phenotype [1]

As primarily secreted proteins, IGFBPs are released into the extracellular space, where they interact with IGF-1 (Oxvig and Conover, 2023)

Vitamin C is one of the most well-researched brightening ingredients available, it directly inhibits melanin production, neutralises free radicals, and boosts collagen synthesis